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Monitor Intently (1)pentobarbital will lessen the level or effect of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to your lessen in fentanyl plasma concentrations, lack of efficacy or, probably, progress of a withdrawal syndrom

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